Description

Uridine, 5'-[Hydrogen p-(Phosphonomethyl)Phosphonate] is a chemically modified nucleoside analog, a key building block in advanced biochemical research and pharmaceutical development. This compound is valued for its role as a potent and specific inhibitor of uridine monophosphate synthase (UMPS), making it a critical tool for studying pyrimidine biosynthesis and related metabolic pathways. It is primarily utilized by researchers and developers in the fields of antiviral drug discovery, oncology research, and molecular biology, where precise biochemical modulation is required.

Application

• Biochemical Research: As a specific inhibitor of uridine monophosphate synthase (UMPS) for studying pyrimidine nucleotide metabolism and enzyme kinetics.
• Antiviral Drug Development: Investigation as a potential nucleoside analog prodrug for targeting viral replication mechanisms.
• Oncology Research: Exploration of its cytostatic effects in cancer cell lines by disrupting de novo pyrimidine synthesis.
• Enzyme Inhibition Studies: Used in high-throughput screening (HTS) assays to identify and characterize new therapeutic targets.
• Metabolic Pathway Analysis: A tool for probing and validating metabolic networks in systems biology.
• Pharmaceutical Intermediates: Serves as a sophisticated synthetic precursor for novel nucleotide-based therapeutics.

Basic Information

Product Name	Uridine, 5'-[Hydrogen p-(Phosphonomethyl)Phosphonate]
CAS No.	732921-73-2
Molecular Formula	C11H16N2O11P2
Molecular Weight	414.20 g/mol
Synonyms	5'-O-[(Phosphonomethyl)phosphonyl]uridine; Uridine 5'-(hydrogen p-(phosphonomethyl)phosphonate); UMPS Inhibitor; 5'-Deoxy-5'-(phosphonomethylphosphonic acid)uridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((((hydroxy(phosphonomethyl)phosphoryl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; p-(Phosphonomethyl)phosphonate Uridine Derivative; NSC 113927
EINECS	Contact for details

Quality Control

Our Uridine, 5'-[Hydrogen p-(Phosphonomethyl)Phosphonate] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.