Description

5-(Chloromethyl)-1,2,3-Trifluoro-Benzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and electron-withdrawing fluorine atoms, makes it a critical intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the stability imparted by the fluorine atoms.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display and lighting applications.
• Polymer & Resin Modification: Employed to introduce functional groups into polymer chains, altering physical and chemical properties for specialty materials.
• Cross-coupling Reactions: Acts as an electrophile in palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig couplings for C-C and C-N bond formation.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution reactions where the chloromethyl group is readily displaced.

Basic Information

Product Name	5-(Chloromethyl)-1,2,3-Trifluoro-Benzene
CAS No.	732306-27-3
Molecular Formula	C7H4ClF3
Molecular Weight	180.55 g/mol
Synonyms	1,2,3-Trifluoro-5-(chloromethyl)benzene; 3,4,5-Trifluorobenzyl Chloride; (3,4,5-Trifluorophenyl)methyl chloride; α-Chloro-3,4,5-trifluorotoluene; 3,4,5-Trifluoro-α-chlorotoluene; 3,4,5-Trifluorobenzylchloride; Benzene, 5-(chloromethyl)-1,2,3-trifluoro-
EINECS	Contact for details

Quality Control

Our 5-(Chloromethyl)-1,2,3-Trifluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to the reactive chloromethyl group, ensure containers are kept tightly sealed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.