Description

2-(3-Fluoro-Phenyl)-Ethanesulfonyl Chloride is a specialized organosulfur building block characterized by its reactive sulfonyl chloride group and fluorinated aromatic ring. This compound is of significant value in medicinal chemistry and advanced material synthesis, serving as a key intermediate for introducing the 3-fluorophenyl-ethanesulfonyl moiety. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly sulfonamide-based therapeutics targeting various diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the sulfonyl group.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and advanced organic frameworks where fluorinated sulfonyl groups impart specific electronic or physical properties.
• Chemical Biology Probes: Serves as a reagent for modifying proteins or other biomolecules to study biological pathways and interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-(3-Fluoro-Phenyl)-Ethanesulfonyl Chloride
CAS No.	728919-65-1
Molecular Formula	C8H8ClFO2S
Molecular Weight	222.66 g/mol
Synonyms	2-(3-Fluorophenyl)ethanesulfonyl chloride; 3-Fluorophenethylsulfonyl chloride; 1-Chlorosulfonyl-2-(3-fluorophenyl)ethane; 2-(3-Fluorophenyl)ethane-1-sulfonyl chloride; (3-Fluorophenyl)ethylsulfonyl chloride; m-Fluorophenethylsulfonyl chloride; 728919-65-1
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Fluoro-Phenyl)-Ethanesulfonyl Chloride is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and synthesis. A detailed Certificate of Analysis (COA) including purity (typically by HPLC/NMR), identity confirmation, and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.