Description

2-(2-Chloro-Phenyl)-Ethanesulfonyl Chloride is a versatile and reactive organosulfur building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both a sulfonyl chloride and an aryl chloride moiety, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel sulfonamides and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing sulfonamide pharmacophores with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the sulfonyl chloride group enables the introduction of specific bioactive moieties.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(2-Chloro-Phenyl)-Ethanesulfonyl Chloride
CAS No.	728919-57-1
Molecular Formula	C8H8Cl2O2S
Molecular Weight	239.12 g/mol
Synonyms	2-(2-Chlorophenyl)ethanesulfonyl chloride; 1-Chloro-2-[2-(chlorosulfonyl)ethyl]benzene; 2-Chlorophenethylsulfonyl chloride; (2-Chlorophenyl)ethanesulfonyl chloride; 2-(2-Chlorophenyl)ethylsulfonyl chloride; o-Chlorophenethylsulfonyl chloride; 2-Chloro-ω-sulfochloroethylbenzene
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Chloro-Phenyl)-Ethanesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and other relevant analytical techniques, is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.