Description

5-[(Pyrrolidine-1-Carbonyl)-Amino]-Naphthalene-1-Sulfonyl Chloride is a specialized organic intermediate featuring a reactive sulfonyl chloride group and a pyrrolidine carboxamide moiety. This compound is valued for its role as a key building block in the synthesis of more complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly those targeting enzymes or receptors where the naphthalene sulfonamide scaffold is relevant.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteases, as the sulfonyl chloride group can react with active site residues.
• Chemical Biology Probe Synthesis: Serves as a starting material for creating activity-based probes (ABPs) to study enzyme function and mechanism in complex biological systems.
• Agrochemical Development: Employed in the research phase for creating new active ingredients with herbicidal or pesticidal properties.
• Material Science: Can be utilized to functionalize surfaces or polymers, introducing specific chemical handles for further modification.
• Peptide & Protein Modification: Acts as a reagent for selectively modifying amino acid side chains (e.g., lysine) in peptides and proteins under controlled conditions.

Basic Information

Product Name	5-[(Pyrrolidine-1-Carbonyl)-Amino]-Naphthalene-1-Sulfonyl Chloride
CAS No.	728864-84-4
Molecular Formula	C15H15ClN2O3S
Molecular Weight	338.81 g/mol
Synonyms	5-[(Pyrrolidine-1-carbonyl)amino]naphthalene-1-sulfonyl chloride; 1-Naphthalenesulfonyl chloride, 5-[(1-pyrrolidinylcarbonyl)amino]-; 5-(Pyrrolidine-1-carboxamido)naphthalene-1-sulfonyl chloride; 5-Amino-N-(1-pyrrolidinylcarbonyl)-1-naphthalenesulfonamide chloride; N-(1-Pyrrolidinylcarbonyl)-5-amino-1-naphthalenesulfonamide chloride; 5-(Pyrrolidine-1-carbonylamino)naphthalene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-[(Pyrrolidine-1-Carbonyl)-Amino]-Naphthalene-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.