Description

Syk Inhibitor II is a potent and selective small molecule inhibitor of the spleen tyrosine kinase (Syk), a key signaling protein in immune cell activation. This compound is a critical research tool for investigating intracellular signaling pathways related to inflammation, autoimmune disorders, and certain hematological cancers. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Biomedical Research: A key reagent for studying B-cell receptor (BCR) and Fc receptor (FcR) signaling pathways in immunology.
• Drug Discovery: Used as a reference compound or positive control in high-throughput screening (HTS) assays to identify novel Syk inhibitors.
• Mechanistic Studies: Essential for elucidating the role of Syk in allergic responses, rheumatoid arthritis, and systemic lupus erythematosus (SLE).
• Oncology Research: Investigated for its potential effects on Syk-dependent signaling in certain lymphomas and leukemias.
• Cellular Assay Development: Employed to validate and optimize cell-based assays measuring phospho-Syk levels or downstream cytokine release.
• Target Validation: Supports in vitro and ex vivo studies to confirm Syk as a therapeutic target for new chemical entities.

Basic Information

Product Name	Syk Inhibitor II
CAS No.	726695-51-8
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	BAY 61-3606; 2-[(7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino]nicotinonitrile; Syk Inhibitor (BAY 61-3606); BAY61-3606; BAY 613606; 6-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-amine; Syk Kinase Inhibitor II
EINECS	Contact for details

Quality Control

Our Syk Inhibitor II is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.