Description

Chk2 Inhibitor CAS NO 724708-21-8 is a potent and selective small molecule inhibitor of the Checkpoint kinase 2 (Chk2) protein, a key regulator in the DNA damage response pathway. This compound is a critical research tool for investigating cell cycle arrest, apoptosis, and DNA repair mechanisms, particularly in the context of cancer biology and therapeutic development. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on oncology, radiobiology, and the development of novel chemotherapeutic adjuvants.

Application

• Oncology Research: Used to study the role of Chk2 in tumor suppression, DNA damage-induced apoptosis, and cellular senescence.
• Drug Discovery & Development: Serves as a pharmacological tool to validate Chk2 as a therapeutic target and to screen for synergistic effects with chemotherapy or radiotherapy.
• Radiobiology Studies: Employed to investigate cellular responses to ionizing radiation and to explore radio-sensitization strategies.
• Cell Cycle Analysis: A key reagent for dissecting checkpoint controls and understanding cell cycle progression following genotoxic stress.
• Biochemical Assays: Used in in vitro kinase assays to determine inhibitory constants (IC50/Ki) and selectivity profiles.
• Academic Research: Facilitates fundamental research into DNA damage signaling pathways and genome stability.

Basic Information

Product Name	Chk2 Inhibitor
CAS No.	724708-21-8
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide; Chk2 Inhibitor II; BML-277; CAS 724708-21-8; Checkpoint kinase 2 inhibitor; 2-[4-(4-Chlorophenoxy)phenyl]-1H-1,3-benzodiazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our Chk2 Inhibitor is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural verification, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.