Description

(S)-3''-Hydroxy Pravastatin Sodium Salt is a key pharmaceutical intermediate and metabolite of the cholesterol-lowering drug Pravastatin. This compound is of significant value for research and development in the pharmaceutical industry, particularly for metabolic studies, impurity profiling, and the synthesis of novel statin derivatives. It is primarily needed by pharmaceutical R&D laboratories, analytical reference standard suppliers, and manufacturers engaged in the development of advanced lipid-regulating therapies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing of Pravastatin and related products.
• Metabolite Research: Serves as a critical standard in pharmacokinetic and pharmacodynamic studies to understand the metabolism, distribution, and efficacy of Pravastatin.
• Impurity Profiling: Essential for identifying and quantifying process-related impurities and degradation products in Pravastatin active pharmaceutical ingredient (API) and finished dosage forms.
• Chemical Synthesis: Acts as a sophisticated building block for the research-scale synthesis of novel statin analogs and prodrugs with potential therapeutic applications.
• Bioanalytical Applications: Employed in the calibration of LC-MS/MS and HPLC systems for the accurate bioanalysis of Pravastatin and its metabolites in biological matrices.

Basic Information

Product Name	(S)-3''-Hydroxy Pravastatin Sodium Salt
CAS No.	722504-45-2
Molecular Formula	C₂₃H₃₅NaO₈
Molecular Weight	462.52 g/mol
Synonyms	(S)-3''-Hydroxy Pravastatin Sodium; 3''-Hydroxy Pravastatin Sodium Salt; Pravastatin 3''-Hydroxy Metabolite Sodium Salt; Sodium (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate; 3α-Hydroxy Pravastatin Sodium; SQ-31906; Pravastatin Hydroxy Acid Sodium Salt (3''-isomer)
EINECS	Contact for details

Quality Control

Our (S)-3''-Hydroxy Pravastatin Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.