Description

[1,4'-Bipiperidine]-1'-Carbonyl-D10-1'-Carboxylic Acid tert-Butyl Ester is a high-purity, deuterated building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled intermediate, enabling precise metabolic and pharmacokinetic studies. This compound is essential for medicinal chemists and researchers in the pharmaceutical industry working on the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders where piperidine scaffolds are prevalent.

Application

• Deuterated Pharmaceutical Intermediate: A critical building block for synthesizing deuterium-labeled active pharmaceutical ingredients (APIs) to enhance metabolic stability and study drug pathways.
• Metabolic Tracer in Drug Discovery: Used in mass spectrometry-based assays for accurate quantification and tracking of drug metabolites in preclinical and clinical studies.
• Neurological & Psychiatric Drug R&D: Serves as a key precursor in the development of deuterated analogs of drugs targeting GPCRs and other central nervous system receptors.
• Isotope-Labeled Standard for Bioanalysis: Employed as an internal standard in LC-MS/MS methods to ensure accurate and reliable quantification of target analytes in complex biological matrices.
• Medicinal Chemistry & Lead Optimization: Facilitates structure-activity relationship (SAR) studies by allowing the strategic incorporation of deuterium to modulate the pharmacokinetic profile of lead compounds.

Basic Information

Product Name	[1,4'-Bipiperidine]-1'-Carbonyl-D10-1'-Carboxylic Acid tert-Butyl Ester
CAS No.	718613-18-4
Molecular Formula	C16D10H18N2O3
Molecular Weight	Contact for details
Synonyms	1,4'-Bipiperidine-1'-carboxylic acid, 1-(1,1-dimethylethyl) D10 ester; tert-Butyl 1,4'-bipiperidine-1'-carboxylate-D10; 1,1'-Bipiperidine-1'-carboxylic acid tert-butyl ester-D10; 4-Piperidinopiperidine-1-carboxylic acid tert-butyl ester-D10; Deuterated BOC-Bipiperidine; BOC-Bipiperidine-D10; 1-BOC-1,4'-Bipiperidine-D10; Deuterated tert-Butyl 4-(piperidin-1-yl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our deuterated chemical products are manufactured under strict quality management systems. Each batch of [1,4'-Bipiperidine]-1'-Carbonyl-D10-1'-Carboxylic Acid tert-Butyl Ester undergoes rigorous analytical testing, including NMR (¹H, ¹³C, and deuterium), HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.