Description

Pf-562271 is a potent and selective small-molecule inhibitor of Focal Adhesion Kinase (FAK), a key signaling protein involved in cell adhesion, migration, and survival. This compound is a critical research tool for investigating the role of FAK in cancer biology, tumor metastasis, and cellular mechanotransduction pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology drug discovery and basic cell signaling research.

Application

• Biochemical Research: Used as a selective FAK inhibitor in enzymatic assays to study kinase activity and inhibition mechanisms.
• Cell-Based Studies: Applied in vitro to investigate the role of FAK in cancer cell proliferation, invasion, and anchorage-independent growth.
• Preclinical Oncology Research: Serves as a reference compound and pharmacological tool in animal models to evaluate FAK as a therapeutic target for solid tumors.
• Signal Transduction Pathway Analysis: Essential for dissecting the FAK/PI3K/AKT and FAK/SRC signaling cascades in various cell types.
• Drug Discovery & Development: Used as a benchmark compound for screening and developing novel FAK-targeted therapeutics.

Basic Information

Product Name	Pf-562271
CAS No.	717907-75-0
Molecular Formula	C₂₃H₂₀F₃N₅O₂
Molecular Weight	455.43 g/mol
Synonyms	PF-562271; PF562271; PF 562271; N-Methyl-4-[[(7-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]methyl]-3-(trifluoromethyl)benzamide; FAK Inhibitor PF-562271; VS-4718; BI-8531 (related analog); Focal Adhesion Kinase Inhibitor PF-562271
EINECS	Contact for details

Quality Control

Our Pf-562271 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for purity, identity, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.