Description

Mcl1-In-1 CAS NO 713492-66-1 is a potent and selective small-molecule inhibitor of the myeloid cell leukemia 1 (Mcl-1) protein, a key anti-apoptotic regulator in the Bcl-2 family. This compound is a critical research tool for investigating programmed cell death pathways and their role in cancer biology and therapeutic resistance. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and the development of novel apoptosis-targeting therapies.

Application

• Biochemical Research: Used as a reference standard and probe compound in in vitro assays to study Mcl-1 protein function and its interactions with other Bcl-2 family members.
• Cancer Biology Studies: Essential for investigating the role of Mcl-1 in tumor cell survival, proliferation, and resistance to chemotherapy and targeted agents.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for screening and validating new Mcl-1 inhibitors in high-throughput and high-content screening platforms.
• Apoptosis Pathway Analysis: Enables detailed mechanistic studies of intrinsic apoptosis signaling, helping to identify biomarkers and therapeutic vulnerabilities.
• Preclinical Evaluation: Supports pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in cell-based and animal models of cancer.

Basic Information

Product Name	Mcl1-In-1
CAS No.	713492-66-1
Molecular Formula	C₂₀H₂₀ClN₅O₂
Molecular Weight	397.86 g/mol
Synonyms	Mcl-1 inhibitor 1; 4-(4-((4-(2-Chlorophenyl)piperazin-1-yl)methyl)piperidin-1-yl)-N-(pyridin-4-ylmethyl)pyrimidin-2-amine; UNC1062; Mcl1-In-1; Mcl-1 Inhibitor; MCL1 inhibitor CAS 713492-66-1; Bcl-2 family inhibitor
EINECS	Contact for details

Quality Control

Every batch of Mcl1-In-1 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, assay results, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.