Description

2-Iodo-5-(Trifluoromethyl)Benzyl Bromide is a versatile and highly functionalized halogenated aromatic building block. This compound is valued for its dual reactive sites, enabling sequential and selective cross-coupling reactions in complex molecule synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing advanced intermediates, particularly those requiring trifluoromethyl and halogen substituents for bioactivity or material properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings, leveraging the iodine and bromine atoms for sequential functionalization.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Fluorine Chemistry Studies: A valuable compound for investigating the influence of the trifluoromethyl group on reaction kinetics and molecular conformation in medicinal chemistry.

Basic Information

Product Name	2-Iodo-5-(Trifluoromethyl)Benzyl Bromide
CAS No.	702641-06-3
Molecular Formula	C8H5BrF3I
Molecular Weight	374.93 g/mol
Synonyms	1-(Bromomethyl)-2-iodo-5-(trifluoromethyl)benzene; α-Bromo-2-iodo-α,α,α-trifluoro-p-xylene; 2-Iodo-α-(bromomethyl)benzotrifluoride; (2-Iodo-5-(trifluoromethyl)phenyl)methyl bromide; Benzene, 1-(bromomethyl)-2-iodo-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-iodobenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance in your sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.