Description

n-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-Cyanophenyl)-1-Methylpropyl]-2-Methyl-2-[(5-(Trifluoromethyl)Pyridin-2-Yl)Oxy]Propanamide (MK-0364) is a high-purity, non-cannabinoid chemical entity designed for advanced pharmaceutical research and development. This compound is of significant interest for its potential as a selective ligand in the study of metabolic and neurological pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents. The material is supplied under strict quality control to ensure consistency and reliability for critical applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug substance and product testing.
• Preclinical Research: Used as a key intermediate or active pharmacological ingredient in in vitro and in vivo studies to investigate biological activity and mechanism of action.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs for new drug candidates.
• Biochemical Assay Development: Acts as a tool compound in high-throughput screening (HTS) and the development of target-specific assays.
• Metabolic Pathway Analysis: Utilized in research focused on understanding and modulating specific enzymatic or receptor-mediated pathways.

Basic Information

Product Name	n-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-Cyanophenyl)-1-Methylpropyl]-2-Methyl-2-[(5-(Trifluoromethyl)Pyridin-2-Yl)Oxy]Propanamide (MK-0364)
CAS No.	701977-09-5
Molecular Formula	C27H25ClF3N3O2
Molecular Weight	515.95 g/mol
Synonyms	MK-0364; MK 0364; MK0364; (1S,2S)-N-[3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide; 2-Methyl-2-[(5-(trifluoromethyl)-2-pyridinyl)oxy]-N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]propanamide
EINECS	Contact for details

Quality Control

Our MK-0364 is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents. We support research and development with materials suitable for use as pharmaceutical reference standards, with purity typically exceeding 98% (by HPLC). Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.