Description

Ly2109761 is a potent and selective small molecule inhibitor of the TGF-β type I receptor kinase, also known as ALK5. This compound is a critical research tool for investigating the TGF-β signaling pathway, which plays a fundamental role in cell proliferation, differentiation, and fibrosis. It is essential for researchers and pharmaceutical developers in oncology, fibrosis research, and cardiovascular disease studies who require high-purity biochemical probes for target validation and mechanism-of-action studies.

Application

• Biochemical Research: Used as a selective inhibitor to study TGF-β/ALK5 signaling pathways in cell-based assays.
• Oncology Research: Investigated for its potential to inhibit epithelial-mesenchymal transition (EMT) and metastasis in cancer models.
• Fibrosis Studies: Applied in research models for renal, hepatic, and pulmonary fibrosis to assess anti-fibrotic effects.
• Cardiovascular Research: Utilized to explore the role of TGF-β signaling in cardiac hypertrophy and vascular remodeling.
• Pharmaceutical Development: Serves as a reference compound or starting point for the development of novel TGF-β pathway therapeutics.
• Academic & Institutional Research: A key reagent for basic science investigations into developmental biology and cellular signaling networks.

Basic Information

Product Name	Ly2109761
CAS No.	700874-71-1
Molecular Formula	C₂₂H₁₉N₅O₂
Molecular Weight	385.42 g/mol
Synonyms	LY2109761; TGF-β Receptor I Kinase Inhibitor II; ALK5 Inhibitor II; 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide; GW788388 (structurally related analog); TGF-beta type I receptor inhibitor
EINECS	Contact for details

Quality Control

Our Ly2109761 is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.