Description

5-(Trifluoromethyl)Pyridin-2-Ol is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group adjacent to a hydroxyl function, makes it an essential intermediate for creating compounds with enhanced metabolic stability and lipophilicity. This product is primarily sought by the pharmaceutical and agrochemical industries for the research and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for metal-organic catalysis and coordination chemistry.
• Material Science Precursor: Acts as a starting material for creating fluorinated liquid crystals, organic semiconductors, and other functional materials.
• Custom Synthesis & R&D: Serves as a versatile scaffold in contract research organizations (CROs) and academic laboratories for exploring new chemical entities.

Basic Information

Product Name	5-(Trifluoromethyl)Pyridin-2-Ol
CAS No.	79894-13-6
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	2-Hydroxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-pyridinol; 2-Pyridinol, 5-(trifluoromethyl)-; 5-Trifluoromethyl-2-hydroxypyridine; 5-Trifluoromethylpyridin-2-ol; 2-Hydroxy-5-trifluoromethylpyridine; α,α,α-Trifluoro-2-hydroxy-5-picoline
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Pyridin-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.