Description

11-Trans Leukotriene D4 is a specific stereoisomer of a potent bioactive lipid mediator derived from arachidonic acid metabolism. This compound is of significant value as a critical reference standard and research tool in the study of inflammatory and allergic pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on respiratory diseases, immunology, and the development of leukotriene receptor antagonists.

Application

• Pharmacological Research: Used as a high-purity reference standard in studies investigating leukotriene receptor binding, signal transduction, and the pathophysiology of asthma and allergic rhinitis.
• Biomarker Development: Serves as a critical calibrant in the development and validation of analytical methods (e.g., LC-MS/MS) for quantifying leukotriene metabolites in biological samples.
• Drug Discovery & Screening: Essential for in vitro and ex vivo bioassays to evaluate the potency and efficacy of novel anti-inflammatory drug candidates targeting the cysteinyl leukotriene pathway.
• Academic & Clinical Studies: Supports fundamental research into the role of specific leukotriene isomers in inflammatory cascades and immune cell activation.
• Quality Control: Acts as a system suitability standard in the pharmaceutical quality control of leukotriene-based therapeutics or related raw materials.

Basic Information

Product Name	11-Trans Leukotriene D4
CAS No.	79768-40-4
Molecular Formula	C25H40N2O7S
Molecular Weight	512.66 g/mol
Synonyms	11-trans-LTD4; (5S,6R)-7-[(1R,2E,4E,6Z,9Z)-1-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-2,4,6,9-heptadecatetraenyl]-5,6-epoxyoxepan-2-one; 11-trans-Leukotriene D4; LTD4 (11-trans isomer); 5(S),6(R)-LTD4 (11-trans); Leukotriene D4, 11-trans-
EINECS	Contact for details

Quality Control

Our 11-Trans Leukotriene D4 is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and isomer-specific analysis. We adhere to relevant guidelines for reference standard materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area dedicated for chemical storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isomeric Purity (11-trans)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.