Description

Prostaglandin I2 11-Methyl Ether is a chemically modified, stable analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is engineered to offer enhanced chemical stability compared to the native prostaglandin, making it a valuable tool for research and development. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and life science companies focused on cardiovascular, pulmonary, and thrombosis-related therapeutics.

Application

• Pharmacological Research: Used as a stable reference standard and active agent in studies investigating vascular tone, platelet function, and pulmonary hypertension.
• Medicinal Chemistry: Serves as a key intermediate or lead compound in the synthesis and development of novel prostaglandin-based pharmaceuticals.
• Biochemical Assays: Employed in in vitro cell-based assays and receptor binding studies to elucidate the PGI2 (IP receptor) signaling pathway.
• Reference Standard: Provides a high-purity calibrant for analytical methods such as HPLC and LC-MS in quality control and metabolic studies.

Basic Information

Product Name	Prostaglandin I2 11-Methyl Ether
CAS No.	79743-30-9
Molecular Formula	C₂₂H₃₄O₆
Molecular Weight	394.50 g/mol
Synonyms	11-Methoxyprostaglandin I2; 11-Methoxy-PGI2; 11-O-Methylprostacyclin; Iloprost Impurity; 5-Heptenoic acid, 6-[(1R,2R,3aS,8bS)-1,2,3a,8b-tetrahydro-2-hydroxy-1-[(3S)-3-hydroxy-1-octen-1-yl]-5-methoxy-2H-cyclopenta[b]benzofuran-8-yl]-; (5Z)-9-Deoxy-6,9α-epoxy-11-methoxy-δ⁵-PGF₁α; 11-Methoxy-δ⁵-PGI₂
EINECS	Contact for details

Quality Control

Our Prostaglandin I2 11-Methyl Ether is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.