Description

Prostaglandin I2 15-Methyl Ether is a chemically modified, stable analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is engineered to offer enhanced metabolic stability and a longer duration of action compared to the native prostaglandin, making it a valuable research tool and a key intermediate in pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly those focused on cardiovascular research, drug discovery, and the synthesis of advanced therapeutic agents.

Application

• Pharmacological Research: Used as a stable reference standard and active agent in studies investigating vascular tone, platelet function, and pulmonary hypertension.
• Drug Discovery & Development: Serves as a critical intermediate or lead compound in the synthesis of novel cardiovascular and anti-thrombotic pharmaceuticals.
• Biochemical Assays: Employed in in vitro and cell-based assays to study prostacyclin receptor (IP receptor) signaling pathways and mechanisms of action.
• Reference Standard: Provides a high-purity benchmark for analytical methods, including HPLC and LC-MS, in quality control and regulatory testing.
• Academic Research: Supports fundamental research in physiology, pharmacology, and medicinal chemistry within university and institutional laboratories.

Basic Information

Product Name	Prostaglandin I2 15-Methyl Ether
CAS No.	79743-29-6
Molecular Formula	C₂₂H₃₄O₆
Molecular Weight	394.50 g/mol
Synonyms	15(S)-15-Methylprostacyclin; 15-Methyl-PGI2; 15-Methylprostacyclin; Iloprost Impurity; Carbacyclin derivative; 15-Methyl Prostaglandin I2; (5Z,9α,11α,13E,15S)-15-Methyl-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic Acid
EINECS	Contact for details

Quality Control

Our Prostaglandin I2 15-Methyl Ether is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your batch.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.