Description

α-Brom-m-Toluolsulfonylfluorid is a specialized organosulfur and organofluorine compound that serves as a versatile building block in advanced organic synthesis. Its unique structure, featuring both a sulfonyl fluoride and a bromomethyl group, makes it a highly reactive and valuable reagent for introducing functional handles into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates, particularly in the development of new active ingredients and materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides that require sulfonyl fluoride or bromomethyl motifs for bioactivity.
• Chemical Biology & Proteomics: Acts as a reactive probe in activity-based protein profiling (ABPP) due to the electrophilic sulfonyl fluoride group, which can covalently label serine hydrolases and other enzymes.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional surfaces.
• Peptide Modification: Employed for the selective modification of peptides and proteins, introducing fluorinated or brominated tags for further conjugation or study.
• Sulfonylating Agent: Used in organic synthesis to introduce the m-toluenesulfonyl (tosyl) group or to create sulfonate esters under mild conditions.

Basic Information

Product Name	α-Brom-m-Toluolsulfonylfluorid
CAS No.	79686-36-5
Molecular Formula	C8H8BrFO2S
Molecular Weight	267.11 g/mol
Synonyms	α-Bromo-m-toluenesulfonyl Fluoride; (Bromomethyl)(3-methylphenyl)sulfonyl Fluoride; 3-Methyl-α-bromobenzenesulfonyl Fluoride; m-Tolylsulfonylfluoromethyl Bromide; Bromo(m-tolylsulfonyl)methane Fluoride; 1-Bromo-1-fluoro(m-tolylsulfonyl)methane; Tosyl Fluoride Bromomethyl Derivative; BTSF (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of α-Brom-m-Toluolsulfonylfluorid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its reactivity as a strong acid/organic solvent type compound, keep away from incompatible materials such as strong bases, amines, and oxidizing agents. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.