Description

9,10-Dihydroxy-7,8-Epoxy-7,8,9,10-Tetrahydro-3-Methylcholanthrene CAS NO 79647-25-9 is a complex polycyclic aromatic hydrocarbon derivative, specifically a dihydrodiol epoxide metabolite of 3-Methylcholanthrene. This compound is of significant interest in biochemical and toxicological research due to its role as a highly reactive intermediate in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical service providers focused on studying DNA adduct formation, mutagenesis, and the metabolic pathways of environmental carcinogens.

Application

• Biochemical Research: Critical standard and reference material for investigating the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs).
• Toxicology Studies: Used in in vitro and in vivo studies to understand carcinogenicity, mutagenicity, and DNA damage mechanisms.
• Analytical Chemistry: Serves as a high-purity analytical standard for method development and validation in HPLC, LC-MS, and GC-MS analysis of PAH metabolites.
• Pharmaceutical R&D: Employed in studies aimed at developing chemopreventive agents or inhibitors that block the formation of such reactive metabolites.
• Environmental Science: Used to calibrate equipment and develop assays for monitoring human exposure to carcinogenic PAHs through biomarker analysis.

Basic Information

Product Name	9,10-Dihydroxy-7,8-Epoxy-7,8,9,10-Tetrahydro-3-Methylcholanthrene
CAS No.	79647-25-9
Molecular Formula	C21H16O3
Molecular Weight	316.35 g/mol
Synonyms	3-Methylcholanthrene 7,8-dihydrodiol 9,10-epoxide; (±)-anti-3-Methylcholanthrene 7,8-diol-9,10-epoxide; anti-3-Methylcholanthrene-7,8-dihydrodiol-9,10-epoxide; 3-MC DE; 3-Methylcholanthrene diol epoxide; MCA dihydrodiol epoxide; 9,10-Epoxy-7,8,9,10-tetrahydro-9,10-dihydroxy-3-methylcholanthrene; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-3-methylcholanthrene
EINECS	Contact for details

Quality Control

Our high-purity 9,10-Dihydroxy-7,8-Epoxy-7,8,9,10-Tetrahydro-3-Methylcholanthrene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under subdued lighting. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Solubility	Soluble in DMSO, Acetone; sparingly soluble in Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.