Description

Brevetoxin B is a potent marine neurotoxin belonging to the class of cyclic polyether compounds, primarily produced by the dinoflagellate *Karenia brevis*. This compound is of significant interest for its specific mechanism of action as a voltage-gated sodium channel activator. It serves as a critical reference standard and research tool for scientists in toxicology, pharmacology, and environmental monitoring, enabling the study of harmful algal blooms (red tides), seafood safety, and neurophysiological pathways.

Application

• Analytical Reference Standard: Primary use as a certified standard for the quantitative analysis of brevetoxins in seawater, shellfish, and other marine samples via HPLC, LC-MS, or ELISA methods.
• Toxicological Research: Fundamental tool for investigating the mechanisms of neurotoxicity, particularly the modulation of voltage-gated sodium channels in neuronal cells.
• Environmental Monitoring & Public Health: Calibration standard for monitoring programs that assess the presence and concentration of red tide toxins to protect public health and fisheries.
• Pharmacological Studies: Used in research to explore potential biomedical applications or to develop antagonists for brevetoxin poisoning.
• Seafood Safety Compliance: Essential for laboratories validating testing protocols to ensure regulatory compliance for shellfish and fish products.
• Antibody & Assay Development: Critical antigen for the development and calibration of immunoassays and biosensors for rapid toxin detection.

Basic Information

Product Name	Brevetoxin B
CAS No.	79580-28-2
Molecular Formula	C50H70O14
Molecular Weight	895.1 g/mol
Synonyms	Brevetoxin B; PbTx-2; GB-2; BTX-B; *Karenia brevis* toxin B; Brevetoxin 2; Marine polyether toxin B; (2S)-2-[(2S,5R,7S,8S,9R,10S,11R,14S,16R,18S,34S,36R,37R,39R,41R,43S,45R,46S,48R)-45,46-Dihydroxy-18,41-dimethoxy-5,7,9,14,37,39,43,48-octamethyl-12,15,31,34-tetraoxaheptacyclo[27.19.2.22,10.02,8.016,43.020,36.026,31]octatetraconta-20,22,24,26(31),27,29-hexaen-11-yl]-6-methylhept-5-en-2-ol
EINECS	Contact for details

Quality Control

Every batch of Brevetoxin B (CAS 79580-28-2) is produced and handled under strict quality protocols to ensure identity, purity, and stability for critical research applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and structural confirmation, to ensure compliance with industry standards for reference materials. Certificates of Analysis (COA) detailing batch-specific purity, analytical methods (e.g., HPLC, NMR), and storage recommendations are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with reference
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.