Description

5-Chloro-3-(trifluoromethyl)-2-pyridinamine is a high-value, halogenated pyridine derivative serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for creating molecules with tailored biological activity and material properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, where the trifluoromethyl group enhances bioavailability and stability.
• Material Science Research: Employed in the synthesis of specialized ligands, functional polymers, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds used in biochemical assay development and target identification.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	5-Chloro-3-(trifluoromethyl)-2-pyridinamine
CAS No.	79456-33-0
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	2-Amino-5-chloro-3-(trifluoromethyl)pyridine; 5-Chloro-3-(trifluoromethyl)pyridin-2-amine; 2-Pyridinamine, 5-chloro-3-(trifluoromethyl)-; 5-Chloro-3-trifluoromethyl-2-pyridylamine; 5-Chloro-α,α,α-trifluoro-2-pyridinamine
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-3-(trifluoromethyl)-2-pyridinamine is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory and chemical hygiene practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.