Description

6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine CAS NO 79456-28-3 is a high-purity, multi-functional pyridine derivative characterized by its chloro and trifluoromethyl substituents. This compound serves as a critical advanced pharmaceutical intermediate and agrochemical building block, enabling the synthesis of novel active ingredients. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate its unique halogenated and fluorinated properties into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used as a building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core and trifluoromethyl group.
• Material Science Research: Employed in the synthesis of functionalized ligands for catalysts or as a monomer for specialty polymers.
• Chemical Biology Probes: Serves as a precursor for labeled compounds or molecular probes used in diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke chemical synthesis projects.

Basic Information

Product Name	6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine
CAS No.	79456-28-3
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	2-Amino-6-chloro-5-(trifluoromethyl)pyridine; 6-Chloro-5-trifluoromethylpyridin-2-amine; 5-(Trifluoromethyl)-6-chloropyridin-2-amine; 2-Pyridinamine, 6-chloro-5-(trifluoromethyl)-; 79456-28-3; 6-Chloro-5-(trifluoromethyl)-2-pyridinamine; 6-Chloro-5-(trifluoromethyl)-2-aminopyridine
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.