Description

L-Leucine-1-13C is a stable isotope-labeled analog of the essential branched-chain amino acid L-Leucine, specifically enriched with carbon-13 at the 1-position. This precise labeling is critical for advanced research applications requiring high sensitivity and accurate metabolic tracing. It is an indispensable tool for scientists and manufacturers in the pharmaceutical, nutritional, and biomedical research sectors who require reliable, high-purity isotopic standards for mass spectrometry, NMR spectroscopy, and metabolic pathway studies.

Application

• Biomedical Research: As an internal standard for the precise quantification of L-Leucine in biological samples using Gas Chromatography-Mass Spectrometry (GC-MS) or Liquid Chromatography-Mass Spectrometry (LC-MS).
• Metabolic Studies: For tracing metabolic fluxes and pathways in cell cultures, animal models, and human clinical research to understand protein synthesis and turnover.
• Pharmaceutical Development: Used in the research and development of new drugs, particularly in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Nutritional Science: Employed in studies investigating amino acid metabolism, requirements, and the efficacy of nutritional supplements and medical foods.
• Proteomics & Stable Isotope Labeling by Amino acids in Cell culture (SILAC): Essential for quantitative proteomics to measure relative protein expression levels in different cell states.
• Diagnostic Agent Development: A potential precursor in the synthesis of 13C-labeled diagnostic probes for breath tests and other non-invasive diagnostic procedures.

Basic Information

Product Name	L-Leucine-1-13C
CAS No.	79292-94-7
Molecular Formula	C513CH13NO2
Molecular Weight	132.16 g/mol
Synonyms	(2S)-2-Amino-4-methyl-1-13C-pentanoic acid; L-(1-13C)Leucine; (S)-2-Amino-4-methyl-1-13C-valeric acid; (S)-2-Amino-4-methyl-1-13C-pentanoic acid; Leucine-1-13C; [1-13C]-L-Leucine; L-Leucine (1-13C); 13C Labeled L-Leucine
EINECS	Contact for details

Quality Control

Every batch of our L-Leucine-1-13C is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including chiral purity to ensure the L-isomer specification. Certificates of Analysis (COA) are provided with each shipment, detailing the isotopic enrichment, chemical purity, and specific analytical results from techniques such as NMR, MS, and HPLC. Our quality commitment supports research requiring traceable and reliable isotopic compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]D20: +14.5° to +16.5° (c=2 in 6N HCl)
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.