Description

n-5-Carboxypentyl-1-Deoxymannojirimycin Methyl Ester is a chemically modified derivative of 1-deoxymannojirimycin (DMJ), designed as a potent and specific inhibitor of Golgi α-mannosidase II. This compound matters for researchers and developers in glycobiology and pharmaceutical discovery, as it is a critical tool for studying N-linked glycan processing and for the development of therapeutics targeting glycosylation-related diseases. Professionals in biotechnology, pharmaceutical R&D, and academic research require this high-purity biochemical for enzyme inhibition studies, probe development, and investigating metabolic disorders like congenital disorders of glycosylation (CDG).

Application

• Glycobiology Research: A key biochemical tool for studying the biosynthesis and processing of N-linked glycans by specifically inhibiting Golgi α-mannosidase II.
• Pharmaceutical Development: Used in drug discovery programs targeting viral infections, cancer, and lysosomal storage diseases where aberrant glycosylation plays a role.
• Enzyme Inhibition Studies: Serves as a reference standard and active compound in assays to characterize mannosidase enzyme kinetics and specificity.
• Metabolic Disorder Research: Applied in cellular and animal models to investigate congenital disorders of glycosylation (CDG) and other metabolic diseases.
• Chemical Probe Synthesis: Acts as a versatile intermediate or precursor for the synthesis of more complex activity-based probes or labeled inhibitors for imaging studies.
• Academic & Industrial R&D: Essential reagent for basic research and applied development in biochemistry, cell biology, and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	n-5-Carboxypentyl-1-Deoxymannojirimycin Methyl Ester
CAS No.	79206-52-3
Molecular Formula	C14H25NO7
Molecular Weight	319.35 g/mol
Synonyms	5-Carboxypentyl-1-deoxymannojirimycin Methyl Ester; Methyl 6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanoate; 1-Deoxymannojirimycin C6-Methyl Ester Derivative; Golgi Mannosidase II Inhibitor Derivative; DMJ-C6-Methyl Ester; N-6-Carboxyhexyl-DMJ Methyl Ester; (2R,3R,4R,5S)-1-(5-Methoxy-5-oxopentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
EINECS	Contact for details

Quality Control

Our n-5-Carboxypentyl-1-Deoxymannojirimycin Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.