Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-, (15R)- is a highly potent cytotoxic ansamycin derivative, serving as a critical intermediate and payload in the development of targeted antibody-drug conjugates (ADCs). Its primary value lies in enabling the creation of next-generation cancer therapeutics that deliver potent cell-killing agents directly to tumor cells, thereby minimizing systemic toxicity. This compound is essential for pharmaceutical R&D teams, biotech companies, and contract research organizations (CROs) focused on oncology drug discovery and advanced bioconjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Payload: As a cytotoxic warhead, it is chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used in biochemical and cellular assays to study mechanisms of tubulin inhibition and apoptosis.
• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of more complex maytansinoid derivatives and prodrugs.
• Preclinical Development: Employed in the formulation and efficacy testing of novel chemotherapeutic agents in animal models.
• Bioconjugation Chemistry Studies: Utilized to develop and optimize novel linker technologies for stable and cleavable ADC constructs.

Basic Information

Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-, (15R)-
CAS No.	79082-29-4
Molecular Formula	C36H50ClN3O10
Molecular Weight	720.25 g/mol
Synonyms	DM1; Mertansine; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; (15R)-15-Hydroxy-3-O-de(2-acetylmethylamino)-1-oxopropylmaytansine; NSC-330507; Immunoconjugate payload DM1
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is moisture-sensitive and should be handled in a controlled, dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.