Description

Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-, (15R)- is a highly potent and structurally complex cytotoxic agent derived from ansamycin antibiotics. This compound is of critical importance as a key payload in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is primarily needed by pharmaceutical research organizations, biotechnology companies, and advanced manufacturers focused on oncology therapeutics and precision medicine.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead conjugated to monoclonal antibodies for targeted delivery to cancer cells.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer treatments.
• Bioconjugation Chemistry: A critical intermediate for developing new linker-payload technologies to improve ADC stability, potency, and therapeutic index.
• Mechanistic Studies: Employed in biochemical assays to study microtubule inhibition and the mechanisms of action of maytansinoid-class compounds.
• Process Development & Scale-Up: Used in the development and optimization of synthetic routes for the commercial production of ADC therapeutics.

Basic Information

Product Name	Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-, (15R)-
CAS No.	79056-16-9
Molecular Formula	C36H48ClN3O10
Molecular Weight	718.23 g/mol
Synonyms	DM4; Mertansine metabolite; Maytansinoid DM4; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; (15R)-15-Hydroxy-3-O-acetyl-2,3-didehydro-3-de-2-(acetylmethylamino)propionylmaytansine; Tubulin inhibitor DM4
EINECS	Contact for details

Quality Control

This high-potency active pharmaceutical ingredient (HPAPI) is manufactured under strict quality systems in compliance with cGMP guidelines. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for bioconjugation and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.