Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-O3-(3-Methyl-1-Oxobutyl)-, (15R)- is a highly potent cytotoxic ansamycin antibiotic and a key structural derivative in the maytansinoid class. This compound serves as a critical payload or linker-payload intermediate in the development of antibody-drug conjugates (ADCs), which are revolutionizing targeted cancer therapies. It is essential for pharmaceutical R&D, process development, and analytical reference applications within the biopharmaceutical and oncology research sectors, where precise molecular engineering is paramount.

Application

• Antibody-Drug Conjugate (ADC) Payload Synthesis: As a potent cytotoxic warhead for conjugation to monoclonal antibodies.
• Linker-Payload Intermediate: Used in the chemical construction of advanced, cleavable, or non-cleavable ADC linker systems.
• Oncology Research & Drug Discovery: A reference standard and building block for developing novel targeted chemotherapeutic agents.
• Process Development & Scale-Up: Serves as a critical intermediate in the GMP manufacturing pathway for clinical-stage ADCs.
• Analytical Standard: Used for method development, validation, and quality control (HPLC, LC-MS) of ADC drugs and related substances.
• Mechanistic Studies: Employed in biochemical research to study tubulin inhibition and mitotic arrest mechanisms.

Basic Information

Item	Details
Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-O3-(3-Methyl-1-Oxobutyl)-, (15R)-
CAS No.	79056-15-8
Molecular Formula	C36H48ClN3O10
Molecular Weight	718.23 g/mol
Synonyms	N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)maytansine; DM1; Mertansine; Maytansinoid DM1; Ansamitocin P-3 derivative; (15R)-15-Hydroxy-3-[(1S)-1-[[(2S)-1-oxo-3-[(2-acetylamino-2-deoxy-β-D-glucopyranosyl)thio]-1-[(phenylmethoxy)carbonylamino]propan-2-yl]amino]-3-methylbutyl]-11-ethyl-4,10-dihydroxy-5,6,9-trimethoxy-8,16-dimethyl-3,7,15-trioxo-1-azahexacyclo[10.7.1.0²,¹⁰.0⁴,⁸.0¹³,¹⁷.0¹⁵,²⁰]icos-13-en-18-yl ester of (2S)-2-amino-3-mercaptopropanoic acid
EINECS	Contact for details

Quality Control

Our Maytansine derivative is produced and controlled under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, related substances, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the sealed container to reach room temperature before opening to prevent condensation. Store in a dedicated, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.