Description

n-Desethyl Amodiaquine Dihydrochloride is a key pharmaceutical intermediate and analytical reference standard, primarily recognized for its role in the synthesis and quality control of the antimalarial drug Amodiaquine. Its importance lies in providing a critical building block for drug development and enabling precise impurity profiling and method validation in pharmaceutical analysis. This high-purity compound is essential for research institutions, pharmaceutical manufacturers, and quality control laboratories focused on antimalarial drug production and regulatory compliance.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of the antimalarial agent Amodiaquine and its derivatives.
• Analytical Reference Standard: Used for the identification, assay, and impurity profiling of Amodiaquine in drug substances and finished products via HPLC, LC-MS, or other chromatographic methods.
• Metabolite Studies: Serves as a reference compound in pharmacokinetic and metabolic studies to understand the biotransformation pathways of Amodiaquine.
• Quality Control & Assurance: Employed in pharmaceutical QC laboratories to validate analytical methods, ensure batch-to-batch consistency, and meet regulatory submission requirements.
• Research & Development: Utilized in medicinal chemistry research for developing new analogs and studying structure-activity relationships (SAR) of 4-aminoquinoline compounds.

Basic Information

Product Name	n-Desethyl Amodiaquine Dihydrochloride
CAS No.	79049-30-2
Molecular Formula	C18H22ClN3O · 2HCl
Molecular Weight	416.21 g/mol (for dihydrochloride salt)
Synonyms	4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol Dihydrochloride; Desethylamodiaquine Dihydrochloride; N-Desethylamodiaquine 2HCl; Amodiaquine Impurity C Dihydrochloride; 2-[(Diethylamino)methyl]-4-[(7-chloroquinolin-4-yl)amino]phenol Dihydrochloride; BSN 107 Dihydrochloride; WR-142,499 Dihydrochloride; AQ-13 Desethyl Metabolite Dihydrochloride
EINECS	Contact for details

Quality Control

Our n-Desethyl Amodiaquine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents, to ensure it meets high-purity standards suitable for pharmaceutical R&D and analytical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.