Description

Maytansine, 2-De(Acetylmethylamino)-15-Hydroxy-, (15R)- is a potent cytotoxic compound belonging to the ansamycin class of natural products. This molecule serves as a critical intermediate and payload in the development of antibody-drug conjugates (ADCs), a revolutionary class of targeted cancer therapeutics. It is essential for pharmaceutical R&D teams and manufacturers specializing in oncology drug development and advanced bioconjugation technologies. The compound's specific stereochemistry and functional groups are key to its biological activity and linker compatibility.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary application as the cytotoxic warhead in targeted cancer therapies.
• Pharmaceutical Intermediate: Used in the synthesis of more complex maytansinoid derivatives and drug candidates.
• Oncology Research: A key reference standard and tool compound for studying microtubule inhibition and apoptosis mechanisms.
• Bioconjugation Chemistry: Serves as a model compound for developing novel linker technologies and conjugation strategies.
• Preclinical Development: Utilized in efficacy and toxicity studies for next-generation targeted chemotherapeutics.

Basic Information

Product Name	Maytansine, 2-De(Acetylmethylamino)-15-Hydroxy-, (15R)-
CAS No.	79028-00-5
Molecular Formula	C34H46ClN3O9
Molecular Weight	676.20 g/mol
Synonyms	DM1; Mertansine; N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; (15R)-15-Hydroxy-2-de(acetylmethylamino)maytansine; NSC-330507; Immunogen mAb-maytansinoid conjugate payload
EINECS	Contact for details

Quality Control

Our Maytansine, 2-De(Acetylmethylamino)-15-Hydroxy-, (15R)- is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We ensure compliance with relevant guidelines for advanced pharmaceutical intermediates, and specifications can be aligned with client requirements for preclinical and clinical-stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-controlled environment. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.