Description

Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-, (15S)- is a highly potent, semi-synthetic derivative of the natural cytotoxin maytansine, designed for targeted therapeutic applications. This compound is a critical intermediate in the synthesis of antibody-drug conjugates (ADCs), enabling the precise delivery of cytotoxic payloads to cancer cells. It is essential for pharmaceutical R&D and manufacturing teams focused on developing next-generation oncology treatments, particularly in the ADC and targeted therapy space.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a potent cytotoxic warhead for conjugation to monoclonal antibodies.
• Oncology Drug Development: A key intermediate in the synthesis of targeted cancer therapeutics.
• Bioconjugation Research: Used in the development of novel linker-payload technologies for targeted drug delivery systems.
• Preclinical & Clinical Studies: Employed in pharmacological and toxicological evaluations of new ADC candidates.
• Pharmaceutical Synthesis: Acts as a sophisticated building block for the manufacture of high-potency active pharmaceutical ingredients (HPAPIs).

Basic Information

Product Name	Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-15-Hydroxy-, (15S)-
CAS No.	79027-99-9
Molecular Formula	C37H51ClN4O10
Molecular Weight	747.28 g/mol
Synonyms	DM4; Maytansinoid DM4; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; (15S)-15-Hydroxy-3-O-acetyl-2-O-de(2-acetylmethylamino)-1-oxopropylmaytansine; Ansamitocin P-3 derivative DM4; NSC 732008; S-methyl DM4 (precursor); Maytansine derivative DM4
EINECS	Contact for details

Quality Control

Our Maytansine derivative DM4 is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided to support your regulatory filings and ensure consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.