Description

5'-p-Fluorosulfonyl-Benzoyladenosine Hydrochloride is a high-purity, chemically modified adenosine derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical sulfonylating reagent and affinity labeling agent, enabling the study and modification of nucleotide-binding sites in enzymes and receptors. It is primarily utilized by pharmaceutical R&D teams, academic biochemists, and contract research organizations (CROs) focused on enzymology, proteomics, and targeted drug discovery.

Application

• Enzyme Active Site Labeling: As an ATP analog for affinity labeling and covalent modification of ATP-binding proteins and kinases.
• Biochemical Probe Synthesis: A key intermediate in the preparation of active site-directed probes for proteomic studies.
• Pharmaceutical Research: Used in the development and screening of novel inhibitors targeting nucleotide-dependent enzymes.
• Structural Biology: A tool for X-ray crystallography and NMR studies to elucidate enzyme mechanisms and binding pockets.
• Diagnostic Reagent Development: Employed in creating components for diagnostic assays that detect specific enzymatic activities.
• Signal Transduction Studies: Investigating purinergic signaling pathways and receptor-ligand interactions.

Basic Information

Product Name	5'-p-Fluorosulfonyl-Benzoyladenosine Hydrochloride
CAS No.	78859-42-4
Molecular Formula	C17H17ClFN5O6S
Molecular Weight	481.86 g/mol
Synonyms	5'-[4-(Fluorosulfonyl)benzoyl]adenosine Hydrochloride; FSBA Hydrochloride; 5'-O-[4-(Fluorosulfonyl)benzoyl]adenosine HCl; Adenosine-5'-[4-(fluorosulfonyl)benzoate] Hydrochloride; p-Fluorosulfonylbenzoyl-5'-adenosine Hydrochloride; 5'-(4-Fluorosulfonylbenzoyl)adenosine HCl; FSBA HCl; ATP Affinity Labeling Reagent
EINECS	Contact for details

Quality Control

Our 5'-p-Fluorosulfonyl-Benzoyladenosine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. A detailed Certificate of Analysis (COA) documenting purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Assay	≥ 98.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.