Description

7-Fluoro-3,4-Dihydro-4-Methyl-1H-1,4-Benzodiazepine-2,5-Dione is a high-purity, fluorinated benzodiazepine derivative, serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its value lies in providing a structurally complex, functionalized scaffold essential for developing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the discovery and production of next-generation central nervous system (CNS) agents and other specialized medicinal compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel benzodiazepine-based and other heterocyclic active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization, particularly for CNS-targeted therapies.
• Preclinical Development: Serves as a starting material or intermediate in the scale-up synthesis of candidate drugs for toxicological and pharmacological evaluation.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of complex molecules for the pharmaceutical industry.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	7-Fluoro-3,4-Dihydro-4-Methyl-1H-1,4-Benzodiazepine-2,5-Dione
CAS No.	78755-80-3
Molecular Formula	C₁₁H₉FN₂O₂
Molecular Weight	220.20 g/mol
Synonyms	4-Methyl-7-fluoro-1,4-benzodiazepine-2,5-dione; 7-Fluoro-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione; 1H-1,4-Benzodiazepine-2,5-dione, 7-fluoro-3,4-dihydro-4-methyl-; 78755-80-3; Fluorinated benzodiazepine dione intermediate
EINECS	Contact for details

Quality Control

Our production of 7-Fluoro-3,4-Dihydro-4-Methyl-1H-1,4-Benzodiazepine-2,5-Dione adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.