Description

3-Chloro-4-Methyl-5-Nitrobenzenesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative essential for advanced organic synthesis. This compound serves as a critical building block for introducing the sulfonamide functional group, enabling the development of molecules with specific biological and chemical properties. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct active ingredients for herbicides, fungicides, and pesticides, leveraging its reactive sulfonyl chloride group.
• Dye and Pigment Manufacturing: Serves as an intermediate for producing sulfonated dyes and colorants with enhanced solubility and fastness properties.
• Polymer Modification: Employed to introduce sulfonamide groups into polymer chains, altering physical properties like solubility, thermal stability, and reactivity.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic pathways and creating specialized chemical libraries.
• Ligand and Catalyst Design: Useful for synthesizing complex ligands and organocatalysts used in asymmetric synthesis and metal complexation.

Basic Information

Product Name	3-Chloro-4-Methyl-5-Nitrobenzenesulfonyl Chloride
CAS No.	78726-74-6
Molecular Formula	C7H5Cl2NO4S
Molecular Weight	278.09 g/mol
Synonyms	5-Nitro-3-chloro-4-methylbenzenesulfonyl chloride; 3-Chloro-4-methyl-5-nitrobenzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-3-chloro-4-methyl-5-nitrobenzene; Benzenesulfonyl chloride, 3-chloro-4-methyl-5-nitro-; 3-Chloro-4-methyl-5-nitrobenzenesulphonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Methyl-5-Nitrobenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.