Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(4-Hydroxy-3-Methyl-1-Oxobutyl)- is a potent cytotoxic agent and a key structural derivative in the maytansinoid class of compounds. Its primary value lies in its role as a critical payload for the development of Antibody-Drug Conjugates (ADCs), a revolutionary class of targeted cancer therapeutics. This high-purity compound is essential for pharmaceutical R&D, process development, and analytical reference standards in oncology research and bioconjugation chemistry.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used in preclinical and clinical studies to investigate mechanisms of action and efficacy of novel maytansinoid-based therapies.
• Bioconjugation Chemistry: A key intermediate for synthesizing novel linker-payload constructs with optimized stability and potency.
• Process Development & Scale-Up: Employed in the development and optimization of manufacturing processes for ADC active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and impurity profiling via HPLC and LC-MS.
• Drug Discovery: A scaffold for medicinal chemistry efforts to create new derivatives with improved therapeutic indices.

Basic Information

Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(4-Hydroxy-3-Methyl-1-Oxobutyl)-
CAS No.	78709-93-0
Molecular Formula	C36H48ClN3O10
Molecular Weight	718.23 g/mol
Synonyms	DM1; Mertansine; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; Maytansinoid DM1; NSC 332598; (2S)-2-[[(3S,4S,5S,6R,8S,10S,11S,12R,13S,14S)-12-[[(2R)-2-Acetyl-2,3-dihydro-1H-indol-1-yl]carbonyloxy]-4-[(2S)-3,3-Dimethyl-2-oxiranyl]-6,8,10,11,13-pentahydroxy-5-methoxy-3,14-dimethyl-1-oxa-4-azacyclotetradec-11-en-5-yl]thio]-N,3-dimethylbutanamide
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured under strict quality systems to ensure the high purity and consistency required for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent demands of ADC payload and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.