Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-19-Dechloro-4,5-Deepoxy-4,5-Didehydro- is a highly potent and structurally complex ansamycin-class cytotoxin. This compound serves as a critical intermediate and payload in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is essential for pharmaceutical R&D, process development, and manufacturing teams focused on next-generation oncology therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary application as the cytotoxic warhead in ADCs targeting specific tumor antigens.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer treatments.
• Bioconjugation Chemistry: Serves as a key intermediate for chemical modification and linker attachment in ADC synthesis.
• Mechanistic Studies: Employed in biochemical assays to study microtubule inhibition and apoptosis induction in cancer cells.
• Process Development: Used in the scale-up and optimization of ADC manufacturing processes under GMP conditions.
• Drug Discovery: A valuable tool compound for screening and validating new targets and delivery mechanisms in oncology.

Basic Information

Item	Details
Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-19-Dechloro-4,5-Deepoxy-4,5-Didehydro-
CAS No.	78630-38-3
Molecular Formula	C35H48ClN3O10
Molecular Weight	706.22 g/mol
Synonyms	DM1; Mertansine; Ansamitocin P-3' derivative; N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)-maytansine; Maytansinoid DM1; NSC-330507; (2S)-2-[[(3S,4S,5S,6R,8S,10S,11S,12R,13S,14S)-12-[[(2R)-2-[(1R)-1-Hydroxyethyl]-5-oxotetrahydrofuran-3-yl]carbamoyl]-4,6,8,12,14-pentahydroxy-11-methoxy-3,5,9,13-tetramethyl-10-[[(2S,3S)-3-methyl-2-(methylamino)-1-oxopentan-3-yl]oxy]-1-oxa-4-azacyclopentadecan-13-yl]thio]-N,3-dimethylbutanamide
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for ADC payload synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to support regulatory filings (e.g., IND, IMPD).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.