Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-4,5-Deepoxy-4,5-Didehydro-22-Demethyl- is a highly potent ansamycin-class cytotoxin that serves as a critical payload in the development of antibody-drug conjugates (ADCs). Its primary value lies in its ability to selectively target and destroy cancer cells when linked to tumor-specific monoclonal antibodies, offering a powerful therapeutic strategy with reduced systemic toxicity. This compound is essential for pharmaceutical R&D teams, biotech companies, and contract research organizations (CROs) focused on advancing next-generation oncology treatments.

Application

• Antibody-Drug Conjugate (ADC) Payload: The primary application is as the cytotoxic warhead in ADCs targeting various cancers, including breast cancer, lymphoma, and leukemia.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel targeted cancer therapies.
• Bioconjugation Chemistry Studies: Serves as a model compound for developing and optimizing linker technologies that control drug release and stability.
• Mechanism of Action Studies: Employed in biochemical assays to study microtubule inhibition and its effects on cell cycle arrest and apoptosis.
• Potency Calibration: Used to calibrate bioassays and cytotoxicity tests due to its well-defined and extreme potency.
• Process Development: Critical for scaling up the synthesis and purification processes required for ADC manufacturing under GMP conditions.

Basic Information

Item	Details
Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-4,5-Deepoxy-4,5-Didehydro-22-Demethyl-
CAS No.	78619-44-0
Molecular Formula	C36H48ClN3O10
Molecular Weight	718.23 g/mol
Synonyms	DM1 (Maytansinoid); Ansamitocin P-3 derivative; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; mertansine; DM1 Maytansinoid; NSC-330507; Immunoconjugate payload DM1; (2S)-2-[[(3S,4R,5S,6S,8S,10S,11S,12R,13S,14S)-12-[[(2R)-2-[(1R)-1-Hydroxyethyl]-5-oxotetrahydrofuran-3-yl]carbamoyl]-4,6,10,12,14-pentamethyl-5-[(2S)-oxiran-2-yl]-11-(propanoyloxy)-3,13-dioxa-2-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-15,17,19-trien-8-yl]sulfanyl]-N,3-dimethylbutanamide
EINECS	Contact for details

Quality Control

Our Maytansine derivative is produced and controlled under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and related substances, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support development efforts aligned with GMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-controlled environment. This compound is both light-sensitive and hygroscopic. For long-term storage, consider storage under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.