Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl-O3-(3-Hydroxy-3-Methyl-1-Oxobutyl)- is a highly potent cytotoxic agent and a key synthetic derivative of the natural ansamycin antibiotic maytansine. This compound is of paramount importance as a critical payload in the development of Antibody-Drug Conjugates (ADCs), enabling targeted cancer therapy with reduced systemic toxicity. It is primarily needed by pharmaceutical R&D departments, biotech companies, and contract manufacturing organizations (CMOs) focused on next-generation oncology therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead conjugated to monoclonal antibodies for targeted cancer cell destruction.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer treatments.
• Bioconjugation Chemistry: A key intermediate for developing novel linker-payload systems with optimized stability and potency.
• Mechanistic Studies: Employed in biochemical assays to study microtubule inhibition and apoptosis induction pathways.
• Process Development: Used in scaling up and optimizing the synthesis of complex ADC payloads under GMP conditions.

Basic Information

Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl-O3-(3-Hydroxy-3-Methyl-1-Oxobutyl)-
CAS No.	78619-43-9
Molecular Formula	C36H50ClN3O10
Molecular Weight	720.25 g/mol
Synonyms	DM1; Mertansine; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; Maytansinoid DM1; NSC 330507; (2S)-2-[[(1S,2R,4S,5S,6S,9R,10S,11S,14S,16R,18S)-5-[(2S)-3-Chloro-2-hydroxy-1-oxopropyl]-18-[(1R)-1-hydroxyethyl]-4,6,10,14-tetramethyl-3,13-dioxo-2,15-dioxabicyclo[12.3.1]octadeca-7,17-dien-11-yl]carbamoyl]-2-methyl-3-sulfanylpropanoyl]-(2-methylalanyl)-N-methyl-L-alaninamide
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot, supporting your regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The material is hygroscopic and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.