Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(3-Hydroxy-3-Methyl-1-Oxobutyl)- is a highly potent cytotoxic agent belonging to the ansamycin class of natural products. This compound serves as a critical payload or linker-payload intermediate in the development of next-generation antibody-drug conjugates (ADCs) for targeted cancer therapy. It is essential for pharmaceutical R&D and manufacturing teams focused on oncology, particularly those developing precision medicines with enhanced therapeutic windows and reduced systemic toxicity.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary application as the cytotoxic warhead conjugated to monoclonal antibodies for targeted delivery to cancer cells.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel cancer therapeutics.
• Linker-Payload Synthesis: Acts as a key intermediate for the chemical synthesis of advanced, cleavable linker systems designed for controlled drug release within tumor cells.
• Mechanistic Studies: Employed in biochemical assays to study microtubule inhibition and apoptosis induction mechanisms.
• Process Development: Serves as a critical material in scaling up and optimizing ADC manufacturing processes under GMP conditions.
• Biosimilar & Novel ADC Development: Essential for companies developing biosimilar ADCs or novel conjugates with improved stability and potency profiles.

Basic Information

Item	Detail
Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-O3-(3-Hydroxy-3-Methyl-1-Oxobutyl)-
CAS No.	78619-41-7
Molecular Formula	C36H48ClN3O10
Molecular Weight	718.23 g/mol
Synonyms	DM1; Mertansine; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; NSC-330507; (2S)-2-[[(2S,3R,4S,5S,6R)-5-[[(2R,3S,4S,6R)-4-(Dimethylamino)-6-[[(2S,3S,6S,7R,8E)-3-hydroxy-3,7,11-trimethyl-8-tridecen-6-yl]oxy]-3-hydroxy-2-tetrahydrofuranyl]methoxy]-4-methoxy-2-methyl-6-(1-oxobutoxy)tetrahydro-2H-pyran-3-yl]amino]-3-mercapto-1-oxopropyl 2-methyl-1-oxo-1,2-dihydro-3H-pyrrolo[3,4-c]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured and controlled under a strict quality management system suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, identity confirmation by spectroscopic methods, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, documenting compliance with client specifications and supporting regulatory filings for investigational new drugs (INDs).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Largest Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.