Description

Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-30-Hydroxy- is a highly potent, semi-synthetic derivative of the natural cytotoxin maytansine, designed for targeted therapeutic applications. This compound is a critical intermediate and payload in the development of Antibody-Drug Conjugates (ADCs), a revolutionary class of biopharmaceuticals for oncology. It is essential for pharmaceutical R&D, process development, and manufacturing teams focused on creating next-generation targeted cancer therapies. The product is supplied with rigorous quality control to ensure batch-to-batch consistency for sensitive bioconjugation processes.

Application

• Primary Payload for Antibody-Drug Conjugates (ADCs): Serves as the cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer cell destruction.
• Oncology Research & Development: Used in preclinical and clinical research to develop novel ADC therapeutics for solid tumors and hematological malignancies.
• Bioconjugation Chemistry Studies: A key substrate for developing and optimizing linker technologies, including cleavable (e.g., disulfide) and non-cleavable (e.g., peptide) linkers.
• Process Development & Scale-Up: Employed in establishing GMP-compliant manufacturing processes for ADC active pharmaceutical ingredients (APIs).
• Potency & Mechanism of Action Studies: Used in assays to study microtubule inhibition, cell cycle arrest, and apoptosis induction in cancer cells.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory filings of ADC-based drugs.

Basic Information

Product Name	Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-30-Hydroxy-
CAS No.	78619-40-6
Molecular Formula	C37H50ClN3O10
Molecular Weight	732.26 g/mol
Synonyms	DM1 (Maytansinoid); Mertansine; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; NSC-330507; (2S)-2-[[(3S,4R,5S,6S,8S,10S,11S,12R,13S,14S)-12-[[(2R)-2-Acetyloxy-1-oxopropyl]amino]-6-[[(2S)-3-[[(2S)-1,4-Dioxo-4-[[(2S,3R)-1-oxo-3-[[(2S,3S)-1-oxo-3-[[(2S)-1-oxo-3-phenyl-2-propanyl]amino]-4-methyl-1-pentanyl]amino]-2-butyl]amino]-2-butanyl]amino]-1-oxo-2-propanyl]amino]-13-[(2R)-2-acetyloxy-1-oxopropyl]-4,10-dihydroxy-5,9,11,13-tetramethyl-2-oxo-3,15-dioxa-10-azabicyclo[10.3.0]pentadec-8-yl]thio]-1-oxopropyl] 2-methylpropanethioate
EINECS	Contact for details

Quality Control

Our Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-30-Hydroxy- is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for ADC payload synthesis. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are provided with every shipment. We support development aligned with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.