Description

Maytansine, 2-De(Acetylmethylamino)-30-Hydroxy-2-Methyl- is a highly potent ansamycin-class cytotoxin, serving as a critical intermediate in the synthesis of antibody-drug conjugates (ADCs). Its value lies in enabling the targeted delivery of potent chemotherapeutic agents directly to cancer cells, thereby minimizing systemic toxicity. This compound is essential for pharmaceutical R&D and manufacturing teams focused on developing next-generation oncology therapeutics, particularly in the ADC and targeted therapy space.

Application

• Antibody-Drug Conjugate (ADC) Payload Synthesis: A key cytotoxic warhead for constructing targeted cancer therapies.
• Oncology Research & Development: Used in preclinical studies to evaluate cytotoxicity and mechanism of action against various cancer cell lines.
• Pharmaceutical Intermediate: Serves as a crucial building block for the chemical modification and production of advanced maytansinoid derivatives.
• Bioconjugation Chemistry: Employed in developing novel linker-payload technologies for targeted drug delivery systems.
• Mechanistic Studies: A tool compound for investigating tubulin inhibition and microtubule destabilization in cellular biology.

Basic Information

Product Name	Maytansine, 2-De(Acetylmethylamino)-30-Hydroxy-2-Methyl-
CAS No.	78619-38-2
Molecular Formula	C34H46ClN3O9
Molecular Weight	676.20 g/mol
Synonyms	2-De(Acetylmethylamino)-30-hydroxy-2-methylmaytansine; DM1; Mertansine; Maytansinoid DM1; Ansamitocin P-3 derivative; NSC-330507; (2S)-2-[[(3S,4S,5S,6R,8S,10S,11S,12R,13S)-12-[[(2R)-2-Acetyloxy-1-oxopropyl]amino]-13-[(2R,5S,9S)-5-Ethyl-5-hydroxy-9-(1-hydroxyethyl)-2-methyl-1,6-dioxonan-9-yl]-4,6,10,12-tetrahydroxy-3,11-dimethoxy-8-methyl-5-oxo-1-oxacyclotetradec-3-en-6-yl]thio]-N,3-dimethylbutanamide
EINECS	Contact for details

Quality Control

Our Maytansine, 2-De(Acetylmethylamino)-30-Hydroxy-2-Methyl- is manufactured under strict quality systems suitable for pharmaceutical research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure high consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be kept in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Related Substances (HPLC)	Individual impurity ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.