Description

1-Alpha, 25-Difluorovitamin D3 is a fluorinated analog of the active form of vitamin D, Calcitriol, designed for enhanced metabolic stability and targeted biological activity. This compound is of significant interest in pharmaceutical research for developing novel therapeutics that modulate calcium homeostasis and cell differentiation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of treatments for bone disorders, certain cancers, and immune system modulation.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of novel vitamin D receptor (VDR) agonists and antagonists.
• Metabolic Studies: Used to investigate the structure-activity relationships of vitamin D analogs, particularly focusing on the impact of fluorine substitution on metabolic pathways and receptor binding affinity.
• Preclinical Drug Development: Serves as a candidate molecule for evaluating therapeutic potential in models of osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Research: Employed as a tool compound to study calcium and phosphate regulation, as well as cell proliferation and differentiation processes.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related vitamin D analogs.

Basic Information

Product Name	1-Alpha, 25-Difluorovitamin D3
CAS No.	78609-64-0
Molecular Formula	C₂₇H₄₂F₂O₃
Molecular Weight	452.62 g/mol
Synonyms	1α,25-Difluorovitamin D3; 1α,25-Difluoro-9,10-secocholesta-5,7,10(19)-triene-3β,25-diol; (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 1,25-difluoro-; 1,25-Difluorocalcitriol; 1α,25-Difluoro-1,25-dihydroxycholecalciferol; 1α,25-Difluoro-1,25-dihydroxyvitamin D3
EINECS	Contact for details

Quality Control

Our 1-Alpha, 25-Difluorovitamin D3 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a Certificate of Analysis (COA) with each shipment, detailing batch-specific results. For research and development purposes, we can supply material compliant with various internal quality standards; custom synthesis and purification to specific requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere at -20°C or below. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.