Description

13,14-Didehydro-20-Methylcarboprostacyclin is a synthetic analog of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. This compound is valued for its enhanced metabolic stability and targeted biological activity, making it a critical intermediate and research tool in advanced pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular, pulmonary, and thrombosis-related drug discovery and development programs.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis of novel therapeutic agents targeting cardiovascular diseases.
• Vasodilation Studies: Used in preclinical and in vitro research to study mechanisms of vasodilation and to model conditions like pulmonary arterial hypertension.
• Platelet Aggregation Inhibition: Employed as a biochemical tool to investigate pathways of platelet activation and to develop new anti-thrombotic therapies.
• Cell Signaling Research: Acts as a potent agonist for prostacyclin (IP) receptors, facilitating studies on cyclic AMP-mediated signaling pathways in various cell types.
• Metabolic Stability Profiling: Utilized in comparative pharmacokinetic studies due to its modified structure designed for improved resistance to enzymatic degradation.

Basic Information

Product Name	13,14-Didehydro-20-Methylcarboprostacyclin
CAS No.	78542-68-4
Molecular Formula	C₂₃H₃₈O₅
Molecular Weight	394.55 g/mol
Synonyms	20-Methylcarboprostacyclin, 13,14-didehydro-; 13,14-Didehydro-20-methyl PGX; 20-Methyl-13,14-didehydrocarbacyclin; 5-Heptenoic acid, 6-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]cyclopentyl]-, methyl ester, (5Z)-; Methyl (5Z)-6-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]cyclopentyl]-5-heptenoate; Carboprostacyclin methyl analog
EINECS	Contact for details

Quality Control

Every batch of 13,14-Didehydro-20-Methylcarboprostacyclin is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.