Description

Teleocidin is a potent indole alkaloid and a member of the teleocidin family of natural products, known for its significant biological activity. This compound is a critical reference standard and research tool in biochemical and pharmacological studies due to its role as a potent activator of protein kinase C (PKC). It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for investigating signal transduction pathways, tumor promotion, and neurobiology.

Application

• Biomedical Research: As a potent PKC activator for studying cellular signaling, differentiation, and apoptosis.
• Pharmacology & Toxicology: Used as a reference standard in studies of tumor promotion and carcinogenesis mechanisms.
• Neuroscience Research: Investigation of neurotransmitter release and neuronal plasticity due to its effects on PKC isoforms.
• Drug Discovery: Serves as a molecular probe for validating drug targets within the PKC pathway and for high-throughput screening assays.
• Academic Research: A key compound for universities and research institutes exploring natural product chemistry and bioactivity.
• Biochemical Reagent: Used in the preparation of specialized cell culture media and experimental buffers for controlled PKC activation.

Basic Information

Product Name	Teleocidin
CAS No.	78474-55-2
Molecular Formula	C29H41N3O2
Molecular Weight	463.66 g/mol
Synonyms	Teleocidin B; Teleocidin B-4; Lyngbyatoxin A; 3,12-Didehydro-6-hydroxy-7,22-dioxo-8-methyl-19-[(1-methyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)methyl]-4,9,17-triazapentacyclo[11.8.0.03,11.05,10.016,21]henicosa-1(13),14,16(21)-triene-20-carboxylic acid methyl ester; (-)-Teleocidin B-4; Teleocidin A (often used interchangeably but structurally distinct)
EINECS	Contact for details

Quality Control

Our Teleocidin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide accurate specifications for the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) when not in use to maintain stability and purity. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.