Description

Gostatin CAS NO 78416-84-9 is a potent and specific inhibitor of aminopeptidase N (APN/CD13), a zinc-dependent metalloprotease. This compound is a critical research tool for studying the role of APN in various biological processes, including tumor angiogenesis, immune regulation, and viral entry. It is essential for researchers and developers in pharmaceutical R&D, academic biochemistry, and cell biology who require high-purity biochemical reagents for mechanistic studies and assay development.

Application

• Biochemical Research: Used as a selective inhibitor to study the enzymatic activity and biological function of aminopeptidase N (APN/CD13) in vitro.
• Oncology Research: Investigated for its anti-angiogenic properties in cancer research, targeting tumor endothelial cell proliferation and metastasis.
• Immunology Studies: Employed to modulate immune cell function, as APN plays a role in peptide processing and antigen presentation.
• Virology Research: Utilized in studies exploring viral entry mechanisms, as some coronaviruses use APN as a cellular receptor.
• Enzyme Assay Development: Serves as a reference standard and control compound in high-throughput screening (HTS) assays for APN inhibitor discovery.
• Pharmaceutical Development: Acts as a lead compound or pharmacophore model for the design of novel therapeutic agents targeting metalloproteases.

Basic Information

Product Name	Gostatin
CAS No.	78416-84-9
Molecular Formula	C₁₀H₁₈N₂O₄
Molecular Weight	230.26 g/mol
Synonyms	Bestatin Hydrochloride; Ubenimex; NK421; ((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine; N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine; Aminopeptidase N Inhibitor; APN Inhibitor
EINECS	Contact for details

Quality Control

Our Gostatin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.