Description

7-Methyl Camptothecin is a potent semi-synthetic derivative of the natural alkaloid camptothecin, known for its significant role as a topoisomerase I inhibitor. This compound is critical for advancing oncology research and the development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on cancer therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced anti-cancer drugs and prodrugs.
• Biochemical Research: Used as a reference standard and tool compound in studies of topoisomerase I inhibition and DNA damage mechanisms.
• Preclinical Development: Essential for in vitro and in vivo efficacy and toxicity studies for new oncology candidates.
• API Manufacturing: Employed in the controlled production of finished dosage forms for clinical trials and commercial supply.
• Mechanistic Studies: Applied in cellular assays to investigate apoptosis, cell cycle arrest, and drug resistance pathways.

Basic Information

Product Name	7-Methyl Camptothecin
CAS No.	78287-26-0
Molecular Formula	C21H18N2O4
Molecular Weight	362.38 g/mol
Synonyms	7-Methylcamptothecin; (S)-7-Methylcamptothecin; 7-Methyl-20(S)-camptothecin; 20(S)-7-Methylcamptothecin; NSC 606985; Camptothecin, 7-methyl-; 4-Ethyl-4-hydroxy-7-methyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	Contact for details

Quality Control

Our 7-Methyl Camptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.