Description

3-Thiomethylparacetamol Glucuronide is a key metabolite and reference standard of the widely used analgesic, paracetamol (acetaminophen). This compound is essential for advanced pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and toxicology. It is primarily required by analytical laboratories, pharmaceutical manufacturers, and academic research institutions for method development, validation, and quality control of related drug products.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of paracetamol metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, bioavailability, and clearance mechanisms of paracetamol and its derivatives.
• Toxicological Research: Employed in studies to understand the formation and role of specific metabolites in drug-induced liver injury and other adverse effects.
• Analytical Method Development: Serves as a high-purity standard for developing and validating HPLC, LC-MS, and GC-MS methods in bioanalytical laboratories.
• Quality Control in Pharma Manufacturing: Used to ensure the purity and consistency of active pharmaceutical ingredients (APIs) and to monitor for specific impurities or degradation products.

Basic Information

Product Name	3-Thiomethylparacetamol Glucuronide
CAS No.	78180-86-6
Molecular Formula	C14H17NO8S
Molecular Weight	359.35 g/mol
Synonyms	Acetaminophen 3-Methylthioether Glucuronide; 3-(Methylthio)paracetamol Glucuronide; 3-Methylthio-4-acetamidophenyl β-D-Glucopyranosiduronic Acid; Paracetamol 3-Methylthioether Glucuronide; 3-Methylmercapto-paracetamol Glucuronide; APAP 3-Methylthioether Glucuronide; N-Acetyl-p-aminophenyl 3-methylthioether glucuronide
EINECS	Contact for details

Quality Control

Our 3-Thiomethylparacetamol Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific client specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.