Description

Methyl Okadaate CAS NO 78111-14-5 is a potent and specific inhibitor of protein phosphatases PP1 and PP2A, making it a critical research tool in cell biology and signal transduction studies. This compound is valued for its ability to induce hyperphosphorylation of proteins, mimicking the effects of okadaic acid with high specificity. It is primarily utilized by researchers in pharmaceutical development, academic biochemistry, and toxicology to investigate cellular processes, apoptosis, and tumor promotion pathways.

Application

• Biochemical Research: As a specific inhibitor of serine/threonine protein phosphatases PP1 and PP2A in in vitro assays.
• Cell Signaling Studies: To induce and study hyperphosphorylation of key regulatory proteins within cellular pathways.
• Toxicology & Cancer Research: Used as a reference compound to study mechanisms of tumor promotion and cellular transformation.
• Neuroscience: Investigation of phosphorylation's role in neuronal function, synaptic plasticity, and neurodegenerative disease models.
• Drug Discovery: A tool compound for validating phosphatase targets and screening for novel therapeutic agents in high-throughput assays.
• Plant Biology: Research into plant defense signaling and stress response mechanisms involving protein phosphorylation.

Basic Information

Item	Details
Product Name	Methyl Okadaate
CAS No.	78111-14-5
Molecular Formula	C₄₄H₆₈O₁₃
Molecular Weight	805.0 g/mol
Synonyms	Methyl Okadaate; Methyl Okadaic Acid; 35-Methylokadaic Acid; 35-Methyl Okadaic Acid; Okadaic Acid Methyl Ester; PP1/PP2A Inhibitor (Methyl Ester); NSC 339511; LCL 242
EINECS	Contact for details

Quality Control

Our Methyl Okadaate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.