Description

3-Chloro-4-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both halogen and trifluoromethyl substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules with fluorine-containing bioactive cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Functional Material Development: Employed in organic synthesis for electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating novel chemical entities in R&D laboratories.

Basic Information

Product Name	3-Chloro-4-Fluorobenzotrifluoride
CAS No.	78068-85-6
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-2-fluoro-5-(trifluoromethyl)benzene; 3-Chloro-4-fluoro-α,α,α-trifluorotoluene; 3-Chloro-4-fluoro(trifluoromethyl)benzene; 2-Fluoro-5-(trifluoromethyl)chlorobenzene; 5-Chloro-4-fluorobenzotrifluoride; 3-Chloro-4-fluorobenzylidene trifluoride; (3-Chloro-4-fluorophenyl)trifluoromethane; 78068-85-6
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzotrifluoride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.48 g/cm³
Boiling Point	~165-168 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.