Description

Iodoacetic Acid, [2-14C] is a carbon-14 labeled derivative of iodoacetic acid, a crucial alkylating agent and metabolic inhibitor. This radiolabeled compound is specifically designed for use in advanced research, enabling precise tracking and quantification in biochemical and metabolic studies. It is an essential tool for scientists in pharmaceutical development, biochemistry, and environmental toxicology who require high-specific-activity tracers for mechanism-of-action and ADME (Absorption, Distribution, Metabolism, and Excretion) research.

Application

• Biochemical Research: As a site-specific alkylating agent to study enzyme active sites, particularly those involving cysteine residues.
• Metabolic Pathway Tracing: Utilizing the carbon-14 label at the 2-position to investigate the metabolic fate of acetic acid derivatives in in vitro and in vivo systems.
• Pharmaceutical Development: A key intermediate in the radiolabeled synthesis of potential drug candidates for pharmacokinetic and biodistribution studies.
• Proteomics & Protein Chemistry: Used for the selective modification of proteins and peptides to understand structure-function relationships.
• Toxicology Studies: Employed to trace the biochemical interactions and metabolic activation of alkylating agents in cellular models.
• Glycolysis Inhibition Studies: Acts as a classical inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in metabolic flux analysis.

Basic Information

Product Name	Iodoacetic Acid, [2-14C]
CAS No.	77898-86-3
Molecular Formula	C2H3IO2 * (14C)
Molecular Weight	Contact for details
Synonyms	2-Iodo[2-14C]acetic Acid; [2-14C]-Iodoacetic Acid; Carboxy-14C-methyl Iodide; (Carboxy-14C)iodomethane; Monoiodo[2-14C]acetic Acid; Radiolabeled Iodoacetate; 14C-IAA
EINECS	Contact for details

Quality Control

Every batch of Iodoacetic Acid, [2-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing, including radiochemical purity analysis by HPLC and TLC, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and solvent composition is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and specific activity. For long-term storage, keep frozen at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR/NMR)	Conforms to structure
Assay (HPLC)	≥ 95% (Chemical Purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified on COA (e.g., Ethanol, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.